Research question
This client research investigates the role of NSD2 in Erastin-induced ferroptosis in keratinocytes.
Omics approach
RNA-Seq compares expression changes, while CUT&Tag examines H3K36me2-associated signals. Together, the measurements link transcriptional changes with epigenetic regulation.
Mechanistic follow-up
Functional experiments examine candidates including NCOA4, LPCAT3 and ATG5. The case illustrates how omics screening can connect with experimental validation.
Paper and source
NSD2 is a critical regulator of Erastin-induced ferroptosis in keratinocytes
Free Radical Biology and Medicine
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