Research question
This client research investigates subcutaneous adipose hyperplasia in facial port-wine stains, connecting cellular composition with regulatory mechanisms.
Omics approach
Single-cell analysis identifies populations including adipose stem and progenitor cells. ATAC and RNA data provide complementary evidence on chromatin accessibility and expression.
Mechanistic follow-up
The study examines how SPSB1 affects HDAC1 degradation and stability, with experimental follow-up including ChIP-qPCR. Multiple data types address a shared mechanistic question.
Paper and source
SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port-Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways
Advanced Science
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